Background: Tumour infiltrating lymphocytes (TILs) is one of the most exciting breast cancer biomarkers, yet no data is available on its prevalence in tumours diagnosed during pregnancy. Methods: We evaluated the prevalence of TILs (stromal and intratumoural) in pregnant and non-pregnant young breast cancer patients. Results: 11/116 (9.6%) of the non-pregnant and 2/86 (2.3%) pregnant patients had TILs≥50% (p<0.001) with highest prevalence observed in triple negative tumours (p=0.01). Conclusions: This is the first report on TILs in tumours diagnosed during pregnancy. The low prevalence could reflect the state of low host immunity associated with pregnancy.
Tumour infiltrating lymphocytes (TILs) in breast cancer during pregnancy / H.A. Azim, A. Vingiani, F. Peccatori, G. Viale, S. Loi, G. Pruneri. - In: THE BREAST. - ISSN 0960-9776. - 24:3(2015 Jun), pp. 290-293.
Tumour infiltrating lymphocytes (TILs) in breast cancer during pregnancy
A. Vingiani;G. Viale;G. PruneriUltimo
2015
Abstract
Background: Tumour infiltrating lymphocytes (TILs) is one of the most exciting breast cancer biomarkers, yet no data is available on its prevalence in tumours diagnosed during pregnancy. Methods: We evaluated the prevalence of TILs (stromal and intratumoural) in pregnant and non-pregnant young breast cancer patients. Results: 11/116 (9.6%) of the non-pregnant and 2/86 (2.3%) pregnant patients had TILs≥50% (p<0.001) with highest prevalence observed in triple negative tumours (p=0.01). Conclusions: This is the first report on TILs in tumours diagnosed during pregnancy. The low prevalence could reflect the state of low host immunity associated with pregnancy.
| File | Dimensione | Formato | |
|---|---|---|---|
|
1-s2.0-S0960977615000107-main.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
421.38 kB
Formato
Adobe PDF
|
421.38 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
