Background: Tumour infiltrating lymphocytes (TILs) is one of the most exciting breast cancer biomarkers, yet no data is available on its prevalence in tumours diagnosed during pregnancy. Methods: We evaluated the prevalence of TILs (stromal and intratumoural) in pregnant and non-pregnant young breast cancer patients. Results: 11/116 (9.6%) of the non-pregnant and 2/86 (2.3%) pregnant patients had TILs≥50% (p<0.001) with highest prevalence observed in triple negative tumours (p=0.01). Conclusions: This is the first report on TILs in tumours diagnosed during pregnancy. The low prevalence could reflect the state of low host immunity associated with pregnancy.
Tumour infiltrating lymphocytes (TILs) in breast cancer during pregnancy / H.A. Azim, A. Vingiani, F. Peccatori, G. Viale, S. Loi, G. Pruneri. - In: THE BREAST. - ISSN 0960-9776. - 24:3(2015 Jun), pp. 290-293.
|Titolo:||Tumour infiltrating lymphocytes (TILs) in breast cancer during pregnancy|
PRUNERI, GIANCARLO (Ultimo)
|Parole Chiave:||Biology; Breast cancer during pregnancy; Tumour infiltrating lymphocytes; Young|
|Settore Scientifico Disciplinare:||Settore MED/08 - Anatomia Patologica|
|Data di pubblicazione:||giu-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.breast.2015.01.009|
|Appare nelle tipologie:||01 - Articolo su periodico|