Objective: Our study purposewas to evaluatemorbidity and postoperative mortality in patients who underwent pelvic exenteration (PE) for primary or recurrent gynecological malignancies. Methods: We identified 230 patients who underwent PE, referred to the gynecological oncology units of 4 institutions: Charitè University in Berlin, Friedrich-Schiller University in Jena, S. Orsola-Malpighi University in Bologna, and Catholic University in Rome and in Campobasso. Results: The median age was 55 years. The tumor site was the cervix in 177 patients, the endometrium in 28 patients, the vulva in 16 patients, and the vagina in 9 patients. Sixty-eight anterior, 31 posterior, and 131 total PEs were performed in 116 women together with hysterectomy. A total of 82.6% of the patients required blood transfusion. The mean operative time was 446 (95-970) minutes, and the median hospitalization was 24 (7-210) days. We noted a major complication rate of 21.3% (n = 49). We registered 7 erioperative deaths (3%) calculated within 30 days. The operation was performed within clear margins in 166 patients (72.2%). The overall mortality rate depending on tumor site at the end of the study was 75%for vulvar cancer, 57.6%for cervical cancer, 55.6%for vaginal cancer, and 53.6% for endometrial cancer. Conclusions: Although an important effort for surgeons and for patients, PE remains a therapeutic option with an acceptable complication rate and postoperative mortality. A strict selection of patients is mandatory to reach adequate surgical and oncologic outcomes.
Morbidity after pelvic exenteration for gynecological malignancies : a retrospective multicentric study of 230 patients / V. Chiantera, M. Rossi, P. De Iaco, C. Koehler, S. Marnitz, A. Fagotti, F. Fanfani, F. Parazzini, R. Schiavina, G. Scambia, A. Schneider, G.F. Vercellino. - In: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. - ISSN 1048-891X. - 24:1(2014 Jan), pp. 156-164.
|Titolo:||Morbidity after pelvic exenteration for gynecological malignancies : a retrospective multicentric study of 230 patients|
|Parole Chiave:||Pelvic exenteration; Morbidity; Mortality; Gynecological malignancies|
|Settore Scientifico Disciplinare:||Settore MED/40 - Ginecologia e Ostetricia|
|Data di pubblicazione:||gen-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/IGC.0000000000000011|
|Appare nelle tipologie:||01 - Articolo su periodico|