Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K + currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.
Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula / F.J. Meye, K. Valentinova, S. Lecca, L. Marion-Poll, M.J. Maroteaux, S. Musardo, I. Moutkine, F. Gardoni, R.L. Huganir, F. Georges, M. Mameli. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - 18:3(2015 Mar), pp. 376-378.
Titolo: | Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula |
Autori: | |
Parole Chiave: | midbrain dopamine neurons; depression; potentiation; withdrawal; activation; mechanisms; model |
Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia |
Data di pubblicazione: | mar-2015 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/nn.3923 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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