Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward processing by regulating glutamatergic inputs. In particular in the striatum the release of DA rapidly influences synaptic transmission modulating both AMPA and NMDA receptors. Several neurodegenerative and neuropsychiatric disorders, including Parkinson, Huntington and addiction-related diseases, manifest a dysregulation of glutamate and DA signaling. Here, we will focus our attention on the mechanisms underlying the modulation of the glutamatergic transmission by DA in striatal circuits.
|Titolo:||Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases|
GARDONI, FABRIZIO (Primo)
|Parole Chiave:||AMPA receptors; Addiction; Dopamine; Huntington disease; NMDA receptor; Parkinson disease|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2015|
|Digital Object Identifier (DOI):||10.3389/fncel.2015.00025|
|Appare nelle tipologie:||01 - Articolo su periodico|