A RAS-related class of small monomeric G proteins, the RAB GTPases, is emerging as of key biological importance in compartment specific directional control of vesicles formation, transport and fusion. Thanks to human genetic observation and to the consequent dedicated biochemical work, substantial progress has been made on the understanding of the role played by RAB GTPases and their effector proteins on neuronal development and the shaping of cognitive functions. This review is highlighting these initial elements to broaden the current scope of research on developmental cognitive deficits and take the point of view of RAB GTPases control on membrane transport in neurons and astrocytes.

RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions [Recensione] / P. D'Adamo, M. Masetti, V. Bianchi, L. Morè, M.L. Mignogna, M. Giannandrea, S. Gatti. - In: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. - ISSN 0149-7634. - 46:special issue(2014 Oct), pp. 302-314.

RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions

M. Masetti;
2014

Abstract

A RAS-related class of small monomeric G proteins, the RAB GTPases, is emerging as of key biological importance in compartment specific directional control of vesicles formation, transport and fusion. Thanks to human genetic observation and to the consequent dedicated biochemical work, substantial progress has been made on the understanding of the role played by RAB GTPases and their effector proteins on neuronal development and the shaping of cognitive functions. This review is highlighting these initial elements to broaden the current scope of research on developmental cognitive deficits and take the point of view of RAB GTPases control on membrane transport in neurons and astrocytes.
Brain development; G proteins; GDI1; GTPase; Intellectual disability; RAB; Behavioral Neuroscience; Cognitive Neuroscience; Neuropsychology and Physiological Psychology
Settore BIO/13 - Biologia Applicata
ott-2014
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/268160
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