Background: Cardiotrophin-1 (CT-1), a cytokine produced by cardiomyocytes and non-cardiomyocytes in conditions of stress, can be used as a biomarker of left ventricular hypertrophy and dysfunction in hypertensive patients. Hypertension is one of the main adverse events in the third and last phase of Fabry's disease (FD). We measured CT-1 in order to examine its correlation with the vascular and cardiac alterations at different ages and assess its potential for use as a biomarker of hypertension in FD. Findings: The level of CT-1 was clearly higher in hypertensive adults than in adult FD patients. FD patients show a small, non-significant decrease in plasma CT-1 with age, while in hypertensive patients CT-1 in plasma rises strongly and highly significantly with age. Conclusions: CT-1 can be considered a good biomarker of the progression of hypertension with age, but particular care is needed when following hypertension in FD patients, since CT-1 does not correlate the same way with this disease.

Hypertension in adult Fabry's disease: is cardiotrophin-1 a diagnostic biomarker? / M.G. Marazzi, E. Galliera, E. Vianello, E. Dozio, A. Stella, G. Tettamanti, L. Tacchini, M.M. Corsi Romanelli. - In: IMMUNITY & AGEING. - ISSN 1742-4933. - 11(2014), pp. 27.1-27.4. [10.1186/s12979-014-0027-3]

Hypertension in adult Fabry's disease: is cardiotrophin-1 a diagnostic biomarker?

M.G. Marazzi
Primo
;
E. Galliera
Secondo
;
E. Vianello;E. Dozio;L. Tacchini
Penultimo
;
M.M. Corsi Romanelli
2014

Abstract

Background: Cardiotrophin-1 (CT-1), a cytokine produced by cardiomyocytes and non-cardiomyocytes in conditions of stress, can be used as a biomarker of left ventricular hypertrophy and dysfunction in hypertensive patients. Hypertension is one of the main adverse events in the third and last phase of Fabry's disease (FD). We measured CT-1 in order to examine its correlation with the vascular and cardiac alterations at different ages and assess its potential for use as a biomarker of hypertension in FD. Findings: The level of CT-1 was clearly higher in hypertensive adults than in adult FD patients. FD patients show a small, non-significant decrease in plasma CT-1 with age, while in hypertensive patients CT-1 in plasma rises strongly and highly significantly with age. Conclusions: CT-1 can be considered a good biomarker of the progression of hypertension with age, but particular care is needed when following hypertension in FD patients, since CT-1 does not correlate the same way with this disease.
Cardiotrophin-1 (CT-1); Fabry disease (FD); Hypertension
Settore MED/05 - Patologia Clinica
Settore MED/04 - Patologia Generale
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
2014
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/267763
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