GOALS: The goal of this study was to evaluate the clinical efficacy of an intake of Lactobacillus salivarius LS01 (DSM 22775) for the treatment of atopic dermatitis (AD) in children. BACKGROUND: AD is an inflammatory and pruritic chronic relapsing skin disorder with multifactorial etiopathology. Some evidence suggests that probiotics may improve AD by modulating the immune system and the composition of intestinal microbiota. STUDY: A total of 43 patients aged from 0 to 11 years were enrolled in the study (M/F ratio=1:1) and treated with the probiotic strain L. salivarius LS01. Clinical efficacy of probiotic treatment was assessed from baseline by changes in itch index and in the objective SCORAD/SCORAD index. RESULTS: Patients being given probiotic treatment showed a significant improvement in clinical parameters (SCORAD and itch values) from baseline. The reduction in SCORAD and itch index observed after 4 weeks of treatment also persisted after the cessation of probiotic supplementation. CONCLUSIONS: L. salivarius LS01 seems to be able to improve the quality of life of children affected by AD and, as a consequence, it may have promising clinical and research implications.

Preliminary results on clinical effects of probiotic Lactobacillus salivarius LS01 in children affected by atopic dermatitis / A.A. Niccoli, A.L. Artesi, F. Candio, S. Ceccarelli, R. Cozzali, L. Ferraro, D. Fiumana, M. Mencacci, M. Morlupo, P. Pazzelli, L. Rossi, M. Toscano, L. Drago. - In: JOURNAL OF CLINICAL GASTROENTEROLOGY. - ISSN 0192-0790. - 48:suppl. 1(2014 Nov), pp. 34-36. [10.1097/MCG.0000000000000233]

Preliminary results on clinical effects of probiotic Lactobacillus salivarius LS01 in children affected by atopic dermatitis

M. Toscano;L. Drago
2014

Abstract

GOALS: The goal of this study was to evaluate the clinical efficacy of an intake of Lactobacillus salivarius LS01 (DSM 22775) for the treatment of atopic dermatitis (AD) in children. BACKGROUND: AD is an inflammatory and pruritic chronic relapsing skin disorder with multifactorial etiopathology. Some evidence suggests that probiotics may improve AD by modulating the immune system and the composition of intestinal microbiota. STUDY: A total of 43 patients aged from 0 to 11 years were enrolled in the study (M/F ratio=1:1) and treated with the probiotic strain L. salivarius LS01. Clinical efficacy of probiotic treatment was assessed from baseline by changes in itch index and in the objective SCORAD/SCORAD index. RESULTS: Patients being given probiotic treatment showed a significant improvement in clinical parameters (SCORAD and itch values) from baseline. The reduction in SCORAD and itch index observed after 4 weeks of treatment also persisted after the cessation of probiotic supplementation. CONCLUSIONS: L. salivarius LS01 seems to be able to improve the quality of life of children affected by AD and, as a consequence, it may have promising clinical and research implications.
No
English
Atopic dermatitis; Gut microbiota; Immune system; Probiotics
Settore MED/07 - Microbiologia e Microbiologia Clinica
Articolo
Esperti anonimi
Pubblicazione scientifica
nov-2014
48
suppl. 1
34
36
3
Pubblicato
Periodico con rilevanza internazionale
pubmed
crossref
Aderisco
info:eu-repo/semantics/article
Preliminary results on clinical effects of probiotic Lactobacillus salivarius LS01 in children affected by atopic dermatitis / A.A. Niccoli, A.L. Artesi, F. Candio, S. Ceccarelli, R. Cozzali, L. Ferraro, D. Fiumana, M. Mencacci, M. Morlupo, P. Pazzelli, L. Rossi, M. Toscano, L. Drago. - In: JOURNAL OF CLINICAL GASTROENTEROLOGY. - ISSN 0192-0790. - 48:suppl. 1(2014 Nov), pp. 34-36. [10.1097/MCG.0000000000000233]
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Prodotti della ricerca::01 - Articolo su periodico
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Article (author)
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A.A. Niccoli, A.L. Artesi, F. Candio, S. Ceccarelli, R. Cozzali, L. Ferraro, D. Fiumana, M. Mencacci, M. Morlupo, P. Pazzelli, L. Rossi, M. Toscano, L...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/266045
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