DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.
Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods / S. Ordanini, N. Varga, V. Porkolab, M. Thépaut, L. Belvisi, A. Bertaglia, A. Palmioli, A. Berzi, D. Trabattoni, M. Clerici, F. Fieschi, A. Bernardi. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - 51:18(2015 Feb 04), pp. 3816-3819.
Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods
S. OrdaniniPrimo
;N. VargaSecondo
;L. Belvisi;A. Palmioli;A. Berzi;D. Trabattoni;M. Clerici;A. BernardiUltimo
2015
Abstract
DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.
| File | Dimensione | Formato | |
|---|---|---|---|
|
C4CC09709B.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
1.83 MB
Formato
Adobe PDF
|
1.83 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
