Tumor recurrence after resection of hepatocellular carcinoma (HCC) can occur early (< 2 years) or late (> 2 years) as metastases or de novo tumors. Interferon (IFN) has the potential for chemoprevention against hepatitis C virus (HCV)-related cirrhosis. A predetermined group of 150 HCV RNA-positive patients undergoing resection of early to intermediate-stage HCC was stratified into 80 HCV-pure (hepatitis B anticore antibody [anti-HBc] -negative) and 70 mixed HCV + hepatitis B virus (HBV) (anti-HBc-positive) groups, then randomized to IFN-alpha (3 million units 3 times every week for 48 weeks [n= 76]) versus control (n= 74). The primary end point was recurrence-free survival (RFS); secondary end points were disease-specific and overall survival. Intention-to-treat and subgroup analysis on adherent patients were conducted. Treatment effects on early/late recurrences were assessed using multiple Cox regression analysis. No patient experienced life-threatening adverse events. There were 28 adherent patients (37%). After 45 months of median follow-up, overall survival was 58.5%, and no significant difference in RFS was detectable between the two study arms (24.3% vs. 5.8%; P= .49). HCC recurred in 100 patients (48 IFN-treated, 52 controls), with a 50% reduction in late recurrence rate in the treatment arm. HCC multiplicity and vascular invasion were significantly related to recurrence (P= .01 and .0003). After viral status stratification, while no treatment effect was apparent in the mixed HCV+HBV population and on early recurrences (72 events), there was a significant benefit on late recurrences (28 events) in HCV-pure patients adherent to treatment (HR: 0.3; 95% CI: 0.09-0.9; P= .04). In conclusion, IFN does not affect overall prevention of HCC recurrence after resection, but it may reduce late recurrence in HCV-pure patients receiving effective treatment.
Prevention of hepatocellular carcinoma recurrence with alpha-interferon after liver resection in HCV cirrhosis / V. Mazzaferro, R. Romito, M. Schiavo, L. Mariani, T. Camerini, S. Bhoori, L. Capussotti, F. Calise, R. Pellicci, G. Belli, A. Tagger, M. Colombo, F. Bonino, P. Majno, J.M. Llovet. - In: HEPATOLOGY. - ISSN 0270-9139. - 44:6(2006 Dec), pp. 1543-1554.
|Titolo:||Prevention of hepatocellular carcinoma recurrence with alpha-interferon after liver resection in HCV cirrhosis|
MAZZAFERRO, VINCENZO MARIA (Primo)
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
Settore MED/42 - Igiene Generale e Applicata
|Data di pubblicazione:||dic-2006|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/hep.21415|
|Appare nelle tipologie:||01 - Articolo su periodico|