We investigated whether a different pattern of HLA-specific inhibitory natural killer receptor (iNKR) expression on peripheral blood mononuclear cells (PBMC) of long-term non-progressor (LTNP) patients explained their benign course of HIV-1 infection. The surface expression of p70, p140 and CD94/NKG2A in their CD3+CD8+ PBMC was comparable to that of uninfected donors. The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients.
|Titolo:||Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients|
|Parole Chiave:||HIV-1 INFECTION ; CELL RECEPTORS ; NONPROGRESSORS ; CD94/NKG2A ; IMPAIRMENT|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||24-gen-2003|
|Digital Object Identifier (DOI):||10.1097/01.aids.0000050798.28043.7a|
|Appare nelle tipologie:||01 - Articolo su periodico|