I.c.v. self-administration of MDMA (0.01-2 μg per infusion), alone and in combination with CP 55,940 (0.4 μg infusion -1), was studied on an operant responding procedure. On the basis of individual preference for one of two levers, developed during training, rats were allowed to self-administer vehicle from the preferred lever and MDMA from the other. Pressings on the MDMA associated-lever, except for the maximal unit dose, progressively increased. The combination of CP 55,940 with MDMA (1 μg infusion -1) reduced the number of drug-associated lever pressings compared to the single drugs. Pre-treatment with SR 141716A (0.5 mg kg -1 i.p.), 15 min before each daily session, significantly increased MDMA self-administration. These findings suggest that MDMA self-administration is under endogenous tonic control by the endocannabinoid system.
Role of the endocannabinoid system in MDMA intracerebral self-administration in rats / D. Braida, M. Sala. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 136:8(2002 Aug), pp. 1089-1092.
|Titolo:||Role of the endocannabinoid system in MDMA intracerebral self-administration in rats|
BRAIDA, DANIELA (Primo)
SALA, MARIAELVINA (Corresponding)
|Parole Chiave:||3,4 methylenedioxymethamphetamine; CP 55,940; SR 141716A; Animals; Cannabinoid Receptor Modulators; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acids, Unsaturated; Hallucinogens; Injections, Intraventricular; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reinforcement (Psychology); Self Administration; Pharmacology|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||ago-2002|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/sj.bjp.0704825|
|Appare nelle tipologie:||01 - Articolo su periodico|
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