A novel one-pot multicomponent synthesis of heteroarylogous 1H-indole-3-carboxamidines starting from readily available N-alkyl-N-(1H-indol-2-ylmethyl)amines, isocyanides, and carbonyl compounds is reported. The strategy exploits the ability of the indole nucleus to interrupt the classical Ugi reaction, by intercepting the nascent nitrilium ion.
Synthesis of heteroarylogous 1H-Indole-3-carboxamidines via a three-component interrupted Ugi reaction / G. Tron, F. La Spisa, F. Meneghetti, B. Pozzi. - In: SYNTHESIS. - ISSN 0039-7881. - 47:4(2015), pp. 489-496.
Synthesis of heteroarylogous 1H-Indole-3-carboxamidines via a three-component interrupted Ugi reaction
F. MeneghettiPenultimo
;
2015
Abstract
A novel one-pot multicomponent synthesis of heteroarylogous 1H-indole-3-carboxamidines starting from readily available N-alkyl-N-(1H-indol-2-ylmethyl)amines, isocyanides, and carbonyl compounds is reported. The strategy exploits the ability of the indole nucleus to interrupt the classical Ugi reaction, by intercepting the nascent nitrilium ion.
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