The paper introduces and studies numerical methods that are fully adaptive in both three-dimensional (3D) space and time to challenging multiscale cardiac reaction-diffusion models. In these methods, temporal adaptivity comes via stepsize control in function space oriented linearly implicit time integration, while spatial adaptivity is realized within multilevel finite element methods controlled by a posteriori local error estimators. In contrast to other recent adaptivity approaches to cardiac modeling that discretize first in space and then in time (so-called method of lines), our method discretizes first in time and then in space (so-called Rothe method)---an approach that has already proven to be highly efficient in a number of challenging multiscale problems in science and technology (KARDOS code library). With this method, the evolution of a complete heartbeat, from the excitation to the recovery phase, is simulated both in the frame of the anisotropic monodomain models and in the more realistic anisotropic bidomain models, coupled with either a variant of the simple FitzHugh--Nagumo model or the more complex phase-I Luo--Rudy ionic model. The numerical results exhibit a rather satisfactory performance of our adaptive method for complex cardiac reaction-diffusion models on 3D domains up to moderate sizes. In particular, the method accurately resolves the evolution of the intra- and extracellular potentials, gating variables, and ion concentrations during the excitation, plateau, and recovery phases.
|Titolo:||Adaptivity in Space and Time for Reaction-Diffusion Systems in Electrocardiology|
PAVARINO, LUCA FRANCO (Ultimo)
|Parole Chiave:||Adaptive finite elements; Adaptive Rothe method; Adaptive time integration; Cardiac bidomain and monodomain models; Error estimates; Multilevel methods; Reaction-diffusion equations|
|Settore Scientifico Disciplinare:||Settore MAT/08 - Analisi Numerica|
|Data di pubblicazione:||2006|
|Digital Object Identifier (DOI):||10.1137/050634785|
|Appare nelle tipologie:||01 - Articolo su periodico|