Exposure to air particulate matter is known to elevate blood biomarkers of inflammation and to increase cardiopulmonary morbidity and mortality. Major components of airborne particulate matter typically include black carbon from traffic and sulfates from coal-burning power plants. DNA methylation is thought to be sensitive to these environmental toxins and possibly mediate environmental effects on clinical outcomes via regulation of gene networks. The underlying mechanisms may include epigenetic modulation of major inflammatory pathways, yet the details remain unclear.

Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study / J.J. Carmona, T. Sofer, J. Hutchinson, L. Cantone, B. Coull, A. Maity, P. Vokonas, X. Lin, J. Schwartz, A.A. Baccarelli. - In: ENVIRONMENTAL HEALTH. - ISSN 1476-069X. - 13(2014 Nov), pp. 94.1-94.14. [10.1186/1476-069X-13-94]

Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study

L. Cantone;
2014

Abstract

Exposure to air particulate matter is known to elevate blood biomarkers of inflammation and to increase cardiopulmonary morbidity and mortality. Major components of airborne particulate matter typically include black carbon from traffic and sulfates from coal-burning power plants. DNA methylation is thought to be sensitive to these environmental toxins and possibly mediate environmental effects on clinical outcomes via regulation of gene networks. The underlying mechanisms may include epigenetic modulation of major inflammatory pathways, yet the details remain unclear.
NF-KAPPA-B; air-pollution; DNA methylation; subclinical atherosclerosis; disease-ontology; incident asthma; lung-function; map kinase; particles; pathway
Settore MED/44 - Medicina del Lavoro
nov-2014
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/260801
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