Stereoselective preparation of 3-hydroxy metabolites of tibolone is easily accomplished by diastereoselective Candida antarctica lipase b-catalyzed transformations of 3alpha- and 3-beta-alcohols or acetates mixtures in organic solvents, in suitable amounts for biological studies.
A practical chemoenzymatic approach to the synthesis of 3-hydroxy metabolites of tibolone / P. Ferraboschi, D. Colombo, S. Reza-Elahi. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 13:23(2002 Nov 26), pp. 2583-2586. [10.1016/S0957-4166(02)00712-7]
A practical chemoenzymatic approach to the synthesis of 3-hydroxy metabolites of tibolone
P. FerraboschiPrimo
;D. ColomboSecondo
;
2002
Abstract
Stereoselective preparation of 3-hydroxy metabolites of tibolone is easily accomplished by diastereoselective Candida antarctica lipase b-catalyzed transformations of 3alpha- and 3-beta-alcohols or acetates mixtures in organic solvents, in suitable amounts for biological studies.
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