Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma biomarker for early subclinical atherosclerosis, as determined by measures of baseline severity and change over time of carotid intima-media thickness (cIMT).
Plasma IL-5 concentration and subclinical carotid atherosclerosis / A. Silveira, O. Mcleod, R.J. Strawbridge, K. Gertow, B. Sennblad, D. Baldassarre, F. Veglia, A. Deleskog, J. Persson, K. Leander, B. Gigante, J. Kauhanen, R. Rauramaa, A.J. Smit, E. Mannarino, P. Giral, S. Gustafsson, S. Söderberg, J. Öhrvik, S.E. Humphries, E. Tremoli, U. de Faire, A. Hamsten. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 239:1(2015 Mar), pp. 125-130. [10.1016/j.atherosclerosis.2014.12.046]
Plasma IL-5 concentration and subclinical carotid atherosclerosis
D. Baldassarre;E. Tremoli;
2015
Abstract
Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma biomarker for early subclinical atherosclerosis, as determined by measures of baseline severity and change over time of carotid intima-media thickness (cIMT).
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