BACKGROUND: Escitalopram is a selective serotonin reuptake inhibitor, widely used in the treatment of affective disorders. The purpose of this study was to examine its safety and tolerability, as mono- versus augmentative therapy, in a group of patients with affective disorders. MATERIALS AND METHODS: The sample consisted of 131 patients suffering from different affective disorders, including major depressive disorder, bipolar disorder, and generalized anxiety disorder, who received escitalopram for at least 4 weeks. Data were analyzed on the basis of mono- versus augmentative therapy, as well as age, gender, mean daily dosage, and patterns of combination therapy. RESULTS: Sixty-seven (51.1%) patients were treated with monotherapy (mean dose of 11.76 mg/day) and 64 (48.9%) with augmentative escitalopram (mean dose of 12.81 mg/day). The mean duration of escitalopram treatment was 14 months. The most frequently combined compounds were: other antidepressants (36.5%), mood stabilizers (33.4%), and atypical antipsychotics (30.1%). Side effects were reported in 5.3% of the total sample and the most common were insomnia (2.3%), nausea (2.3%), and dizziness (0.8%). No significant difference, in terms of tolerability, in mono- versus augmentative therapy groups was found. In addition, neither age nor gender was significantly correlated with a greater presence of side effects. Finally, no significant correlation between dosage and side effects was observed. CONCLUSION: Over a 14-month observation period, escitalopram, either as monotherapy or an augmentative treatment, was found to be well tolerated in a large sample of patients with affective disorders, with an overall low rate of side effects.
Escitalopram tolerability as mono- versus augmentative therapy in patients with affective disorders : a naturalistic study / B. Dell'osso, C. Arici, C. Dobrea, G. Camuri, B. Benatti, A.C. Altamura. - In: NEUROPSYCHIATRIC DISEASE AND TREATMENT. - ISSN 1178-2021. - 9(2013), pp. 205-209.
|Titolo:||Escitalopram tolerability as mono- versus augmentative therapy in patients with affective disorders : a naturalistic study|
DELL'OSSO, BERNARDO MARIA (Primo)
ARICI, CHIARA (Secondo)
ALTAMURA, ALFREDO CARLO (Ultimo)
|Parole Chiave:||affective disorders; augmentative therapy; escitalopram; monotherapy; tolerability|
|Settore Scientifico Disciplinare:||Settore MED/25 - Psichiatria|
|Data di pubblicazione:||2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2147/NDT.S39322|
|Appare nelle tipologie:||01 - Articolo su periodico|