The incidence of chronic pain is estimated to be 20-25% worldwide. Although major improvements in pain control have been obtained, more than 50% of the patients reports inadequate relief. It is accepted that chronic pain, if not adequately and rapidly treated, can become a disease in itself, often intractable and maybe irreversible. This is mainly due to neuroplasticity of pain pathways. In the present review I will discuss about pain depicting the rational for the principal pharmacological interventions and finally focusing on opioids, that represent a primary class of drug to treat pain.
|Titolo:||Pain pharmacology : focus on opioids|
FORNASARI, DIEGO MARIA MICHELE (Primo)
|Parole Chiave:||Chronic pain; Multi-target pharmacology; Opioids; Tapentadol|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||set-2014|
|Digital Object Identifier (DOI):||10.1138/ccmbm/2014.11.3.165|
|Appare nelle tipologie:||01 - Articolo su periodico|