Fifteen new galactoglycerolipid analogues, in which one or two branched, alicyclic or aromatic acyl chains are linked to 2-O-beta-D-galactosylglycerol (6'-position or 1,6' positions), were prepared and tested for their anti-tumor-promoting activity using a short-term in vitro assay for Epstein-Barr virus early antigen (EBV-EA) activation. All compounds were active in inhibiting the EBV activation promoted by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), the branched compounds resulting in the most active glycoglycerolipid analogues of the series. The branched 2-O-[6-O-(3-methylbutanoyl)-beta-D-galactopyranosyl]-sn-glycerol (1a) and the structurally related alicyclic 2-O-[6-O-(2-cyclohexylethanoyl)-beta-D-galactopyranosyl]-sn-glycerol (1d), when tested in an in vivo two-stage carcinogenesis test, exhibited inhibitory effects on mouse skin tumor promotion.
Cyclic and branched acyl chain galactoglycerolipids and their effect on anti-tumor-promoting activity / D. Colombo, L. Franchini, L. Toma, F. Ronchetti, R. Tanaka, J. Takayasu, H. Nishino, H. Tokuda. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 41:12(2006 Dec), pp. 1456-1463.
|Titolo:||Cyclic and branched acyl chain galactoglycerolipids and their effect on anti-tumor-promoting activity|
COLOMBO, DIEGO RODOLFO (Primo)
FRANCHINI, LAURA (Secondo)
|Parole Chiave:||Cancer chemoprevention; Epstein-Barr virus; Glycoglycerolipids|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||dic-2006|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejmech.2006.07.007|
|Appare nelle tipologie:||01 - Articolo su periodico|