BACKGROUND AND PURPOSE: Anti-sulfatide immunoglobulin M (IgM) antibodies have been associated with different forms of neuropathies but their diagnostic role in neuropathy remains unclear. METHODS: The clinical association of increased titers of anti-sulfatide IgM antibodies in 570 patients with neuropathy and related disorders examined in our laboratory since 2004 was reviewed. Sera were tested by enzyme-linked immunosorbent assay at the initial serum dilution of 1:32 000 and titrated by serial two-fold dilution. In all positive patients IgM antibodies to myelin-associated glycoprotein (MAG) were also measured by western blot. RESULTS: High titers of anti-sulfatide antibodies were found in 39 patients including 33 (85%) who also had anti-MAG IgM. Six patients did not have anti-MAG IgM including five in whom moderately increased anti-sulfatide titers were associated with different forms of neuropathy. One patient with a demyelinating neuropathy and IgM monoclonal gammopathy had markedly increased anti-sulfatide titers (1:256 000). CONCLUSIONS: Increased titers of anti-sulfatide IgM antibodies are not infrequent in patients with neuropathy where they are often associated with a concomitant reactivity to MAG. A selective reactivity to sulfatide, however, is rarely found and is associated with different forms of neuropathy limiting its usefulness in the diagnosis of neuropathy.
Anti-sulfatide IgM antibodies in peripheral neuropathy : to test or not to test? / C. Giannotta, C. Balducci, F. Gallia, D. Di Pietro, E. Nobile-Orazio. - In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. - ISSN 1529-8027. - 22:5(2015), pp. 879-882. ((Intervento presentato al 4. convegno Congresso della Associazione Italiana sul Sistema Nervoso Periferico tenutosi a Sorrento nel 2014.
|Titolo:||Anti-sulfatide IgM antibodies in peripheral neuropathy : to test or not to test?|
GIANNOTTA, CLAUDIA ELVIRA (Primo)
DI PIETRO, DAVIDE ANTONIO (Penultimo)
NOBILE-ORAZIO, EDUARDO (Ultimo)
|Parole Chiave:||IgM; antibodies; autoimmunity; neuropathy; sulfatide|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||2015|
|Enti collegati al convegno:||Associazione Italiana sul Sistema Nervoso Periferico|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/ene.12658|
|Appare nelle tipologie:||01 - Articolo su periodico|