Functionalized bicyclic lactams serve as building blocks for the synthesis of conformationally constrained peptides. A route to these building blocks is described based on the stereoselective alkylation of an appropriate azabicycloalkane; all possible diastereoisomers can be obtained stereoselectively.
Synthesis of functionalized azabicycloalkane amino acids as dipeptide mimics / L. MANZONI, L. BELVISI, E. DICARLO, A. FORNI, D. INVERNIZZI, C. SCOLASTICO. - In: SYNTHESIS. - ISSN 0039-7881. - :7(2006), pp. 1133-1140.
Synthesis of functionalized azabicycloalkane amino acids as dipeptide mimics
L. BELVISISecondo
;E. DICARLO;D. INVERNIZZIPenultimo
;C. SCOLASTICOUltimo
2006
Abstract
Functionalized bicyclic lactams serve as building blocks for the synthesis of conformationally constrained peptides. A route to these building blocks is described based on the stereoselective alkylation of an appropriate azabicycloalkane; all possible diastereoisomers can be obtained stereoselectively.
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