Human immunodeficiency virus (HIV) is still a huge health problem, causing the death of over 1 million people per year. The search for HIV-entry inhibitors represents a promising challenge to prevent HIV infection. In this field, DC-SIGN, a receptor expressed at the surface of the mucosal dendritic cells and involved in the early stages of HIV infection, is an important cellular target.1 DC-SIGN is a calcium-dependant tetrameric lectin, which recognizes and binds high-mannose oligosaccharides displayed at the surface of HIV virus.
New DC-SIGN ligands with a rigid core of controlled length / S. Ordanini, V. Porkolab, F. Fieschi, A. Bernardi. ((Intervento presentato al convegno MultiGlycoNano COST Meeting tenutosi a Siena nel 2014.
New DC-SIGN ligands with a rigid core of controlled length
S. Ordanini;A. Bernardi
2014
Abstract
Human immunodeficiency virus (HIV) is still a huge health problem, causing the death of over 1 million people per year. The search for HIV-entry inhibitors represents a promising challenge to prevent HIV infection. In this field, DC-SIGN, a receptor expressed at the surface of the mucosal dendritic cells and involved in the early stages of HIV infection, is an important cellular target.1 DC-SIGN is a calcium-dependant tetrameric lectin, which recognizes and binds high-mannose oligosaccharides displayed at the surface of HIV virus.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
