Lantibiotics 97518 and NAI-107, produced by the related genera Planomonospora and Microbispora respectively, are members of a family of nisin-related compounds. They represent promising compounds to treat infections caused by multiresistant Gram-positive pathogens. Despite their similar structure and a similar antibacterial spectrum, the two lantibiotics exhibit significant differences in their potency. To gain an insight into the structure–activity relationships, their conformational properties in solution are determined by NMR. After carrying out an NOE analysis of 2D 1H NMR spectra, high-resolution 3D structures are determined using molecular dynamics simulations.

Solution structure by nuclear magnetic resonance of the two lantibiotics 97518 and NAI-107 / F. Vasile, D. Potenza, B. Marsiglia, S. Maffioli, S. Donadio. - In: JOURNAL OF PEPTIDE SCIENCE. - ISSN 1075-2617. - 2012:2(2012 Feb), pp. 129-134.

Solution structure by nuclear magnetic resonance of the two lantibiotics 97518 and NAI-107

F. Vasile
;
D. Potenza
Secondo
;
2012

Abstract

Lantibiotics 97518 and NAI-107, produced by the related genera Planomonospora and Microbispora respectively, are members of a family of nisin-related compounds. They represent promising compounds to treat infections caused by multiresistant Gram-positive pathogens. Despite their similar structure and a similar antibacterial spectrum, the two lantibiotics exhibit significant differences in their potency. To gain an insight into the structure–activity relationships, their conformational properties in solution are determined by NMR. After carrying out an NOE analysis of 2D 1H NMR spectra, high-resolution 3D structures are determined using molecular dynamics simulations.
3D structure; Dynamic simulation; Lantibiotic; Nuclear magnetic resonance
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/256356
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