The development of efficient methods for the combinatorial synthesis of N-glycosyl conjugates is vital for many fields of modern synthetic organic chemistry. Herein, we report a multicomponent domino process for the regioselective synthesis of a large array N-glycosyl-Asp-urea conjugates, which could be further functionalized in a chemoselective way, starting from easily accessible reactants such as N-glycosylamines, fumaric acid monoesters, azides, and isocyanates. The process occurs under very mild conditions, does not require the use of strong bases/acids or high temperature, and is highly versatile, working efficiently with a range of protecting groups and substituents.
Synthesis of N-glycosyl conjugates through a multicomponent domino process / M.C. Bellucci, A. Volonterio. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2014:11(2014 Apr), pp. 2386-2397.
Titolo: | Synthesis of N-glycosyl conjugates through a multicomponent domino process |
Autori: | BELLUCCI, MARIA CRISTINA (Primo) |
Parole Chiave: | Domino reactions; Glycoconjugates; Multicomponent reactions; Regioselectivity |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica |
Data di pubblicazione: | apr-2014 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/ejoc.201301887 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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