We read with interest the Article by Masaaki Yamamoto and colleagues1 about the use of stereotactic radiosurgery in patients with one to ten brain metastases. Their prospective, observational study was well designed and they enrolled many patients (n=1194); nevertheless, their findings raise several relevant questions about stereotactic radiosurgery and whole-brain radiotherapy. We have several concerns about the study. First, overall survival is not an appropriate primary endpoint to assess the effectiveness of a local therapy such as brain stereotactic radiosurgery.
Stereotactic radiosurgery for patients with brain metastases / F. Alongi, A. Fiorentino, P. Navarria, L. Bello, M. Scorsetti. - In: THE LANCET ONCOLOGY. - ISSN 1470-2045. - 15:7(2014 Jun), pp. e246-e247.
Stereotactic radiosurgery for patients with brain metastases
L. Bello;
2014
Abstract
We read with interest the Article by Masaaki Yamamoto and colleagues1 about the use of stereotactic radiosurgery in patients with one to ten brain metastases. Their prospective, observational study was well designed and they enrolled many patients (n=1194); nevertheless, their findings raise several relevant questions about stereotactic radiosurgery and whole-brain radiotherapy. We have several concerns about the study. First, overall survival is not an appropriate primary endpoint to assess the effectiveness of a local therapy such as brain stereotactic radiosurgery.
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