The structural properties of the lipids forming biological membranes determine a very high level of lateral organization within membranes. Lipid-driven membrane organization allows the segregation of membrane-associated components into membrane lipid domains, now worldwide known as lipid rafts, acting as dynamic platforms for signal transduction, protein processing and membrane turnover. Many processes necessary to the correct functions of nervous system occur in lipid rafts and are dependent on lipid raft organization. Thus, an altered lipid composition frequently occurring in neurodegenerative diseases leads to anomalous lipid raft organization and then to deregulated cell signaling.
Membrane lipid domains in the nervous system / S. Sonnino, M. Aureli, L. Mauri, M.G. Ciampa, A. Prinetti. - In: FRONTIERS IN BIOSCIENCE. - ISSN 1093-4715. - 20:2(2015 Jan 01), pp. 280-302. [10.2741/4309]
Membrane lipid domains in the nervous system
S. SonninoPrimo
;M. AureliSecondo
;L. Mauri;M.G. CiampaPenultimo
;A. PrinettiUltimo
2015
Abstract
The structural properties of the lipids forming biological membranes determine a very high level of lateral organization within membranes. Lipid-driven membrane organization allows the segregation of membrane-associated components into membrane lipid domains, now worldwide known as lipid rafts, acting as dynamic platforms for signal transduction, protein processing and membrane turnover. Many processes necessary to the correct functions of nervous system occur in lipid rafts and are dependent on lipid raft organization. Thus, an altered lipid composition frequently occurring in neurodegenerative diseases leads to anomalous lipid raft organization and then to deregulated cell signaling.File | Dimensione | Formato | |
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