Microvesicles (MVs) are released from almost all cell brain types into the microenvironment and are emerging as a novel way of cell-to-cell communication. This review focuses on MVs discharged by microglial cells, the brain resident myeloid cells, which comprise ~10-12% of brain population. We summarize first evidence indicating that MV shedding is a process activated by the ATP receptor P2X7 and that shed MVs represent a secretory pathway for the inflammatory cytokine IL-β. We then discuss subsequent findings which clarify how IL-1 P can be locally processed and released from MVs into the extracellular environment. In addition, we describe the current understanding about the mechanism of P2X 7-dependent MV formation and membrane abscission, which, by involving sphingomyelinase activity and ceramide formation, may share similarities with exosome biogenesis. Finally we report our recent results which show that microglia-derived MVs can stimulate neuronal activity and participate to the propagation of inflammatory signals, and suggest new areas for future investigation.

Microglial microvesicle secretion and intercellular signaling / E. Turola, R. Furlan, F. Bianco, M. Matteoli, C. Verderio. - In: FRONTIERS IN PHYSIOLOGY. - ISSN 1664-042X. - 3(2012), pp. 149.1-149.11.

Microglial microvesicle secretion and intercellular signaling

E. Turola;R. Furlan;M. Matteoli;
2012

Abstract

Microvesicles (MVs) are released from almost all cell brain types into the microenvironment and are emerging as a novel way of cell-to-cell communication. This review focuses on MVs discharged by microglial cells, the brain resident myeloid cells, which comprise ~10-12% of brain population. We summarize first evidence indicating that MV shedding is a process activated by the ATP receptor P2X7 and that shed MVs represent a secretory pathway for the inflammatory cytokine IL-β. We then discuss subsequent findings which clarify how IL-1 P can be locally processed and released from MVs into the extracellular environment. In addition, we describe the current understanding about the mechanism of P2X 7-dependent MV formation and membrane abscission, which, by involving sphingomyelinase activity and ceramide formation, may share similarities with exosome biogenesis. Finally we report our recent results which show that microglia-derived MVs can stimulate neuronal activity and participate to the propagation of inflammatory signals, and suggest new areas for future investigation.
Brain inflammation; IL-beta; Microglial cells; Microvesicles; Neuronal activity
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/254849
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