A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2'-(7-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ligand for subsequent 68Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed.
Biocompatible nanocomposite for PET/MRI hybrid imaging / E. Locatelli, L. Gil, L.L. Israel, L. Passoni, M. Naddaka, A. Pucci, T. Reese, V. Gomez-Vallejo, P. Milani, M. Matteoli, J. Llop, J.P. Lellouche, M. Comes Franchini. - In: INTERNATIONAL JOURNAL OF NANOMEDICINE. - ISSN 1176-9114. - 7(2012), pp. 6021-6033.
|Titolo:||Biocompatible nanocomposite for PET/MRI hybrid imaging|
LOCATELLI, ERICA (Primo)
|Parole Chiave:||maghemite nanoparticles; magnetic resonance imaging; organic coating; polymeric nanoparticles; positron emission tomography; radiolabeling; biocompatible materials; contrast media; gallium radioisotopes; image enhancement; magnetic resonance imaging; magnetite nanoparticles; nanostructures; positron-emission tomography; radiopharmaceuticals; biophysics; bioengineering; biomaterials; organic chemistry; drug discovery3003 pharmaceutical science|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2147/IJN.S38107|
|Appare nelle tipologie:||01 - Articolo su periodico|
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