Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the "APS Task Force 3-Laboratory Diagnostics and Trends" meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, RJ, Brazil).

14. International congress on antiphospholipid antibodies task force. Report on antiphospholipid syndrome laboratory diagnostics and trends / M.L. Bertolaccini, O. Amengual, L. Andreoli, T. Atsumi, C.B. Chighizola, R. Forastiero, P. de Groot, G. Lakos, M. Lambert, P. Meroni, T.L. Ortel, M. Petri, A. Rahman, R. Roubey, S. Sciascia, M. Snyder, A.E. Tebo, A. Tincani, R. Willis. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - 13:9(2014 Sep), pp. 917-930. [10.1016/j.autrev.2014.05.001]

14. International congress on antiphospholipid antibodies task force. Report on antiphospholipid syndrome laboratory diagnostics and trends

C.B. Chighizola;P. Meroni;
2014-09

Abstract

Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the "APS Task Force 3-Laboratory Diagnostics and Trends" meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, RJ, Brazil).
antiprothrombin antibodies; domain I; IgA; lupus anticoagulant; risk; aCL
Settore MED/16 - Reumatologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/254393
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