The family of mammalian sialidases is composed of four distinct versatile enzymes that remove negatively charged terminal sialic acid residues from gangliosides and glycoproteins in different subcellular areas and organelles, including lysosomes, cytosol, plasma membrane and mitochondria. In this review we summarize the growing body of data describing the important role of sialidases in skeletal muscle, a complex apparatus involved in numerous key functions and whose functional integrity can be affected by various conditions, such as aging, chronic diseases, cancer and neuromuscular disorders. In addition to supporting the proper catabolism of glycoconjugates, sialidases can affect different signaling pathways by desialylation of many receptors and modulation of ganglioside content in cell membranes, thus actively participating in myoblast proliferation, differentiation and hypertrophy, insulin responsiveness and skeletal muscle architecture.
Implications for the mammalian sialidases in the physiopathology of skeletal muscle / A. Fanzani, A. Zanola, F. Faggi, N. Papini, B. Venerando, G. Tettamanti, M. Sampaolesi, E. Monti. - In: SKELETAL MUSCLE. - ISSN 2044-5040. - 2:1(2012 Nov 01), pp. 23.1-23.10.
|Titolo:||Implications for the mammalian sialidases in the physiopathology of skeletal muscle|
|Parole Chiave:||gangliosides; glycoproteins; myogenesis; sialidases; skeletal muscle; molecular biology; cell biology; orthopedics and sports medicine|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||1-nov-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1186/2044-5040-2-23|
|Appare nelle tipologie:||01 - Articolo su periodico|