We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.

Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy / F. Notturno, T. Di Febo, N. Yuki, B.M. Fernandez Rodriguez, D. Corti, E. Nobile-Orazio, M. Carpo, A. De Lauretis, A. Uncini. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 276:1-2(2014), pp. 207-212. [10.1016/j.jneuroim.2014.09.001]

Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

E. Nobile-Orazio;M. Carpo;
2014

Abstract

We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.
Chronic inflammatory demyelinating neuropathy; Gliomedin; Multifocal motor neuropathy; Neurofascin
Settore MED/26 - Neurologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/253177
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