Deficiency of vitamin K predisposes to early, classic or late hemorrhagic disease of the newborn (HDN); of which late HDN may be associated with serious and life-threatening intracranial hemorrhage. Late HDN is characterized intracranial bleeding in infants aged 1 week to 6 months due to severe vitamin K deficiency. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. Children with cholestatic liver disease are at risk for developing secondary vitamin K deficiency because of fat malabsorbtion and inadequate dietary intake. In this study, we described 11 infants with cholestatic liver disease with different etiologies exhibiting intracranial hemorrhage (ICH). Six patients underwent surgical evacuation of ICH, following the administration of vitamin K and/or fresh frozen plasma. The possibility of cholestatic liver disease should be considered in the treatment of ICH due to vitamin K deficiency.

Frequency and time to relapse after discontinuation of six months therapy with IVIg or IV Methylprednisolone in patients with CIDP (IMC follow-up study) / E. Nobile-Orazio, D. Cocito, S. Jann, A. Uncini, P. Messina, G. Antonini, R. Fazio, F. Gallia, A. Schenone, A. Francia, D. Pareyson, L. Santoro, S. Tamburin, R. Macchia, E. Beghi, G. Cavaletti, F. Giannini, M. Sabatelli. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 34:Supplement(2013 Oct), pp. 51-52. ((Intervento presentato al 44. convegno Congresso della Società Italiana di Neurologia tenutosi a Milano nel 2013 [10.1007/s10072-012-0965-5].

Frequency and time to relapse after discontinuation of six months therapy with IVIg or IV Methylprednisolone in patients with CIDP (IMC follow-up study)

E. Nobile-Orazio
Primo
;
F. Gallia;
2013

Abstract

Deficiency of vitamin K predisposes to early, classic or late hemorrhagic disease of the newborn (HDN); of which late HDN may be associated with serious and life-threatening intracranial hemorrhage. Late HDN is characterized intracranial bleeding in infants aged 1 week to 6 months due to severe vitamin K deficiency. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. Children with cholestatic liver disease are at risk for developing secondary vitamin K deficiency because of fat malabsorbtion and inadequate dietary intake. In this study, we described 11 infants with cholestatic liver disease with different etiologies exhibiting intracranial hemorrhage (ICH). Six patients underwent surgical evacuation of ICH, following the administration of vitamin K and/or fresh frozen plasma. The possibility of cholestatic liver disease should be considered in the treatment of ICH due to vitamin K deficiency.
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/253147
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