The diagnosis of small fiber neuropathy (SFN) has been recently defined as typical symptoms due to small nerve fiber dysfunction accompanied by reduced intra-epidermal nerve fiber density (IENFD) or abnormal temperature threshold testing (TTT). Guidelines have been published for the assessment of IENFD. However, international guidelines for TTT are lacking. This paper presents a systematic literature review on reported TTT methods and provides recommendations for its future use in studies evaluating patients. A total of 164 papers fulfilled pre-defined requirements and were selected for review. Over 15 types of instruments are currently being used with a variety of methodological approaches for location, stimulus application, and sensation qualities examined. Consensus is needed to standardize the use of TTT as a diagnostic and follow-up tool in patients.
Can electrophysiology predict outcomes in CIDP? / D. Cocito, E. Nobile-Orazio, S. Jann, A. Uncini, E. Beghi, G. Antonini, R. Fazio, A. Schenone, A. Francia, D. Pareyson, L. Santoro, S. Tamburin, R. Macchia, E. Peci, I. Palolasso, G. Cavaletti, F. Giannini, M. Sabatelli. - In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. - ISSN 1529-8027. - 18:suppl. 1(2013), pp. S7-S7. (Intervento presentato al 3. convegno Annual Meeting of the Associazione-Italiana-Sistema-Nervoso-Periferico tenutosi a Verona nel 2013) [10.1111/jns5.12015].
Can electrophysiology predict outcomes in CIDP?
E. Nobile-OrazioSecondo
;
2013
Abstract
The diagnosis of small fiber neuropathy (SFN) has been recently defined as typical symptoms due to small nerve fiber dysfunction accompanied by reduced intra-epidermal nerve fiber density (IENFD) or abnormal temperature threshold testing (TTT). Guidelines have been published for the assessment of IENFD. However, international guidelines for TTT are lacking. This paper presents a systematic literature review on reported TTT methods and provides recommendations for its future use in studies evaluating patients. A total of 164 papers fulfilled pre-defined requirements and were selected for review. Over 15 types of instruments are currently being used with a variety of methodological approaches for location, stimulus application, and sensation qualities examined. Consensus is needed to standardize the use of TTT as a diagnostic and follow-up tool in patients.
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