Rational: We retrospectively analyzed 232 patients affected by well differentiated ductal intraepithelial neoplasia (DIN1c or DCIS G1) treated with conservative surgery without adjuvant radiotherapy. Results: 25 invasive and 18 non-invasive local recurrences were observed ( median follow-up 80 months; 5-year cumulative incidence: 12.2%). Seven of the 15 young patients (<40 y) developed local recurrence (2 in situ, 5 invasive). Age <50 (HR 1.89, 95% C.I. 1.01-3.45), multifocality (HR 3.21, 95% C.I. 1.46-7.06), Ki-67 > 7% (HR 2.33, 95% C.I. 1.20-4.55) and surgical margins <10 mm (HR 2.00, 95% C.I. 1.06-3.76) were significantly associated with an increased risk of local recurrence. Conclusions: Young age, multifocality and small margins appeared as clear risk factors of local recurrence in DIN1c (DCIS G1) population. The presence of multiple poor prognostic features warrant a thorough discussion regarding local treatment.
Breast conservative surgery for well-differentiated ductal intraepithelial neoplasia : risk factors for ipsilateral breast tumor recurrence / A. Toesca, E. Botteri, M. Lazzeroni, J. Vila, A. Manika, B. Ballardini, F. Bettarini, A. Guerrieri Gonzaga, B. Bonanni, N. Rotmensz, G. Viale, P. Veronesi, A. Luini, U. Veronesi, O. Gentilini. - In: THE BREAST. - ISSN 0960-9776. - 23:6(2014 Dec), pp. 829-835. [10.1016/j.breast.2014.08.016]
Breast conservative surgery for well-differentiated ductal intraepithelial neoplasia : risk factors for ipsilateral breast tumor recurrence
G. Viale;P. Veronesi;
2014
Abstract
Rational: We retrospectively analyzed 232 patients affected by well differentiated ductal intraepithelial neoplasia (DIN1c or DCIS G1) treated with conservative surgery without adjuvant radiotherapy. Results: 25 invasive and 18 non-invasive local recurrences were observed ( median follow-up 80 months; 5-year cumulative incidence: 12.2%). Seven of the 15 young patients (<40 y) developed local recurrence (2 in situ, 5 invasive). Age <50 (HR 1.89, 95% C.I. 1.01-3.45), multifocality (HR 3.21, 95% C.I. 1.46-7.06), Ki-67 > 7% (HR 2.33, 95% C.I. 1.20-4.55) and surgical margins <10 mm (HR 2.00, 95% C.I. 1.06-3.76) were significantly associated with an increased risk of local recurrence. Conclusions: Young age, multifocality and small margins appeared as clear risk factors of local recurrence in DIN1c (DCIS G1) population. The presence of multiple poor prognostic features warrant a thorough discussion regarding local treatment.File | Dimensione | Formato | |
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