Objective: Transcranial Direct Current Stimulation (tDCS) over the cerebellum (or cerebellar tDCS) modulates working memory, changes cerebello-brain interaction, and affects locomotion in humans. Also, the use of tDCS has been proposed for the treatment of disorders characterized by cerebellar dysfunction. Nonetheless, the electric field (E) and current density (J) spatial distributions generated by cerebellar tDCS are unknown. This work aimed to estimate E and J distributions during cerebellar tDCS. Methods: Computational electromagnetics techniques were applied in three human realistic models of different ages and gender. Results: The stronger E and J occurred mainly in the cerebellar cortex, with some spread (up to 4%) toward the occipital cortex. Also, changes by ±1. cm in the position of the active electrode resulted in a small effect (up to 4%) in the E and J spatial distribution in the cerebellum. Finally, the E and J spreads to the brainstem and the heart were negligible, thus further supporting the safety of this technique. Conclusions: Despite inter-individual differences, our modeling study confirms that the cerebellum is the structure mainly involved by cerebellar tDCS. Significance: Modeling approach reveals that during cerebellar tDCS the current spread to other structures outside the cerebellum is unlike to produce functional effects. © 2013 International Federation of Clinical Neurophysiology.

Modeling the current density generated by transcutaneous spinal direct current stimulation (tsDCS) / M. Parazzini, S. Fiocchi, I. Liorni, E. Rossi, F. Cogiamanian, M. Vergari, A. Priori, P. Ravazzani. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 125:11(2014 Apr 03), pp. 11.2260-11.2270. [10.1016/j.clinph.2014.02.027]

Modeling the current density generated by transcutaneous spinal direct current stimulation (tsDCS)

F. Cogiamanian;A. Priori
Penultimo
;
2014

Abstract

Objective: Transcranial Direct Current Stimulation (tDCS) over the cerebellum (or cerebellar tDCS) modulates working memory, changes cerebello-brain interaction, and affects locomotion in humans. Also, the use of tDCS has been proposed for the treatment of disorders characterized by cerebellar dysfunction. Nonetheless, the electric field (E) and current density (J) spatial distributions generated by cerebellar tDCS are unknown. This work aimed to estimate E and J distributions during cerebellar tDCS. Methods: Computational electromagnetics techniques were applied in three human realistic models of different ages and gender. Results: The stronger E and J occurred mainly in the cerebellar cortex, with some spread (up to 4%) toward the occipital cortex. Also, changes by ±1. cm in the position of the active electrode resulted in a small effect (up to 4%) in the E and J spatial distribution in the cerebellum. Finally, the E and J spreads to the brainstem and the heart were negligible, thus further supporting the safety of this technique. Conclusions: Despite inter-individual differences, our modeling study confirms that the cerebellum is the structure mainly involved by cerebellar tDCS. Significance: Modeling approach reveals that during cerebellar tDCS the current spread to other structures outside the cerebellum is unlike to produce functional effects. © 2013 International Federation of Clinical Neurophysiology.
Computational modeling; High resolution human models; Spinal non-invasive neuromodulation technique; TsDCS
Settore MED/26 - Neurologia
Settore BIO/09 - Fisiologia
Settore M-PSI/01 - Psicologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/252268
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