Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates protein folding and trafficking. Although CyPA was initially believed to function primarily as an intracellular protein, recent studies have revealed that it can be secreted by cells in response to inflammatory stimuli. Current research in animal models and humans has provided compelling evidences supporting the critical function of CyPA in several human diseases. This review discusses recently available data about CyPA in cardiovascular diseases, viral infections, neurodegeneration, cancer, rheumatoid arthritis, sepsis, asthma, periodontitis and aging. It is believed that further elucidations of the role of CyPA will provide a better understanding of the molecular mechanisms underlying these diseases and will help develop novel pharmacological therapies.

Cyclophilin A : a key player for human disease / P. Nigro, G. Pompilio, M.C. Capogrossi. - In: CELL DEATH & DISEASE. - ISSN 2041-4889. - 4:10(2013 Oct 31), pp. e888.1-e888.10. [10.1038/cddis.2013.410]

Cyclophilin A : a key player for human disease

G. Pompilio
Secondo
;
2013

Abstract

Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates protein folding and trafficking. Although CyPA was initially believed to function primarily as an intracellular protein, recent studies have revealed that it can be secreted by cells in response to inflammatory stimuli. Current research in animal models and humans has provided compelling evidences supporting the critical function of CyPA in several human diseases. This review discusses recently available data about CyPA in cardiovascular diseases, viral infections, neurodegeneration, cancer, rheumatoid arthritis, sepsis, asthma, periodontitis and aging. It is believed that further elucidations of the role of CyPA will provide a better understanding of the molecular mechanisms underlying these diseases and will help develop novel pharmacological therapies.
Cancer; Cardiovascular diseases; CyPA; Neurodegeneration; Rheumatoid arthritis; Viral infections; Animals; Arthritis, Rheumatoid; Cardiovascular Diseases; Cyclophilin A; Humans; Neurodegenerative Diseases; Cell Biology; Immunology; Cancer Research; Cellular and Molecular Neuroscience
Settore BIO/11 - Biologia Molecolare
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/252221
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