Atypical chemokine receptors are a distinct subset of chemokine receptors able to modulate immune responses by acting as chemokine decoy/scavengers or transporters. Intracellular trafficking properties sustained by Gαi-independent signaling have emerged as a major determinant of their biological properties, which support continuous uptake, transport, and/or concentration, of the ligands. Here, we are providing methods to study both trafficking and signaling of this class of chemokine receptors focusing on the atypical chemokine receptor D6 that degrades inflammatory CC chemokines. © 2013 Elsevier Inc.
Dissecting trafficking and signaling of atypical chemokine receptors / E. Borroni, C. Cancellieri, M. Locati, R. Bonecchi - In: VOLUME 521 G protein coupled receptors: trafficking and oligomerization[s.l] : P. Michael Conn, 2013. - pp. 151-168
Titolo: | Dissecting trafficking and signaling of atypical chemokine receptors |
Autori: | BORRONI, ELENA MONICA (Primo) CANCELLIERI, CINZIA (Secondo) LOCATI, MASSIMO (Penultimo) BONECCHI, RAFFAELLA (Ultimo) |
Parole Chiave: | β-Arrestin; Atypical chemokine receptors; Chemokine; GPCR signaling; GPCR trafficking |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
Data di pubblicazione: | 2013 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/B978-0-12-391862-8.00008-9 |
Tipologia: | Book Part (author) |
Appare nelle tipologie: | 03 - Contributo in volume |