Atypical chemokine receptors are a distinct subset of chemokine receptors able to modulate immune responses by acting as chemokine decoy/scavengers or transporters. Intracellular trafficking properties sustained by Gαi-independent signaling have emerged as a major determinant of their biological properties, which support continuous uptake, transport, and/or concentration, of the ligands. Here, we are providing methods to study both trafficking and signaling of this class of chemokine receptors focusing on the atypical chemokine receptor D6 that degrades inflammatory CC chemokines. © 2013 Elsevier Inc.

Dissecting trafficking and signaling of atypical chemokine receptors / E. Borroni, C. Cancellieri, M. Locati, R. Bonecchi - In: VOLUME 521 G protein coupled receptors: trafficking and oligomerization[s.l] : P. Michael Conn, 2013. - pp. 151-168 [10.1016/B978-0-12-391862-8.00008-9]

Dissecting trafficking and signaling of atypical chemokine receptors

E. Borroni;C. Cancellieri;M. Locati;R. Bonecchi
2013

Abstract

Atypical chemokine receptors are a distinct subset of chemokine receptors able to modulate immune responses by acting as chemokine decoy/scavengers or transporters. Intracellular trafficking properties sustained by Gαi-independent signaling have emerged as a major determinant of their biological properties, which support continuous uptake, transport, and/or concentration, of the ligands. Here, we are providing methods to study both trafficking and signaling of this class of chemokine receptors focusing on the atypical chemokine receptor D6 that degrades inflammatory CC chemokines. © 2013 Elsevier Inc.
β-Arrestin; Atypical chemokine receptors; Chemokine; GPCR signaling; GPCR trafficking
Settore MED/04 - Patologia Generale
Book Part (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/252114
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact