Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.
Tertiary lymphoid tissue : a gateway for T cells in the tumor microenvironment / G. di Caro, F. Marchesi. - In: ONCOIMMUNOLOGY. - ISSN 2162-4011. - 3:5(2014), pp. e28850.1-e28850.3. [10.4161/onci.28850]
Tertiary lymphoid tissue : a gateway for T cells in the tumor microenvironment
F. MarchesiUltimo
2014
Abstract
Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.
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