In the previous issue of Arthritis Research & Therapy, Muro and colleagues reported a detailed epidemiologic analysis in central Japan on one of the new myositis-specific autoantibodies to MDA-5 (melanoma differentiation-associated gene 5), which is associated with clinically amyopathic dermatomyositis accompanying interstitial lung disease. The increasing prevalence of anti-MDA-5, higher prevalence in small rural towns, and geographical clustering in two areas along the Kiso River suggest a role of environmental factors associated with rural communities or the river/water system or both. A detailed analysis of a small cohort may offer clues, which is ignored in multi-center studies, to the pathogenesis of systemic rheumatic diseases and autoantibody production. © 2012 BioMed Central Ltd.
Role of environmental factors in autoantibody production-importance of a detailed analysis in a small cohort / M. Satoh, A. Ceribelli, E.K.L. Chan. - In: ARTHRITIS RESEARCH & THERAPY. - ISSN 1478-6354. - 14:1(2012 Feb 29), pp. 109.1-109.2.
Role of environmental factors in autoantibody production-importance of a detailed analysis in a small cohort
A. CeribelliSecondo
;
2012
Abstract
In the previous issue of Arthritis Research & Therapy, Muro and colleagues reported a detailed epidemiologic analysis in central Japan on one of the new myositis-specific autoantibodies to MDA-5 (melanoma differentiation-associated gene 5), which is associated with clinically amyopathic dermatomyositis accompanying interstitial lung disease. The increasing prevalence of anti-MDA-5, higher prevalence in small rural towns, and geographical clustering in two areas along the Kiso River suggest a role of environmental factors associated with rural communities or the river/water system or both. A detailed analysis of a small cohort may offer clues, which is ignored in multi-center studies, to the pathogenesis of systemic rheumatic diseases and autoantibody production. © 2012 BioMed Central Ltd.File | Dimensione | Formato | |
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