Rheumatoid arthritis (RA) is a chronic and severe autoimmune disease that affects joint tissues, bone, and cartilage. However, the pathogenesis of RA is still unclear. Autoantibodies such as rheumatoid factor and anti-cyclic citrullinated peptide are useful tools for early diagnosis, monitoring disease activity, and predicting prognosis. Recently, many groups have focused their attention on the role of microRNAs in the pathogenesis of RA, as well as a potential biomarker to monitor RA. In fact, the expression of some microRNAs, such as miR-146a, is upregulated in different cell types and tissues in RA patients. MicroRNAs in RA could also be considered as possible future targets for new therapeutic approaches. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

MicroRNAs in rheumatoid arthritis / A. Ceribelli, M.A. Nahid, M. Satoh, E.K.L. Chan. - In: FEBS LETTERS. - ISSN 0014-5793. - 585:23(2011), pp. 3667-3674.

MicroRNAs in rheumatoid arthritis

A. Ceribelli
Primo
;
2011

Abstract

Rheumatoid arthritis (RA) is a chronic and severe autoimmune disease that affects joint tissues, bone, and cartilage. However, the pathogenesis of RA is still unclear. Autoantibodies such as rheumatoid factor and anti-cyclic citrullinated peptide are useful tools for early diagnosis, monitoring disease activity, and predicting prognosis. Recently, many groups have focused their attention on the role of microRNAs in the pathogenesis of RA, as well as a potential biomarker to monitor RA. In fact, the expression of some microRNAs, such as miR-146a, is upregulated in different cell types and tissues in RA patients. MicroRNAs in RA could also be considered as possible future targets for new therapeutic approaches. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Autoimmunity; Innate immunity; microRNA; miR-146a; Rheumatoid arthritis; Animals; Arthritis, Rheumatoid; Humans; Immune System; MicroRNAs; Models, Immunological; Biochemistry; Biophysics; Cell Biology; Genetics; Molecular Biology; Structural Biology
Settore MED/16 - Reumatologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/251852
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