The increasing use of moderate (<35 fractions) and extreme (<5 fractions) hypofractionated radiation therapy in prostate cancer is yielding favorable results, both in terms of maintained biochemical response and toxicity. Several hypofractionation (HF) schemes for the treatment of prostate cancer are available, although there is considerable variability in the techniques used to manage intra-/interfraction motion and deliver radiation doses. We performed a review of the published studies on HF regimens as a topic of interest for the Stereotactic Ablative Radiotherapy working group, which is part of the Italian Association of Medical Physics. Aspects of organ motion management (imaging for contouring, target volume definition, and rectum/bladder preparation) and treatment delivery (prostate localization, image guided radiation therapy strategy and frequency) were evaluated and categorized to assess outcome relative to disease control and toxicity. Despite the heterogeneity of the data, some interesting trends that emerged from the review might be useful in identifying an optimum HF strategy.

Role of the technical aspects of hypofractionated radiation therapy treatment of prostate cancer : a review / S. Clemente, R. Nigro, C. Oliviero, C. Marchioni, M. Esposito, F.R. Giglioli, P. Mancosu, C. Marino, S. Russo, M. Stasi, L. Strigari, I. Veronese, V. Landoni. - In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. - ISSN 0360-3016. - 91:1(2015 Jan 01), pp. 182-195. [10.1016/j.ijrobp.2014.08.006]

Role of the technical aspects of hypofractionated radiation therapy treatment of prostate cancer : a review

I. Veronese
Penultimo
;
2015

Abstract

The increasing use of moderate (<35 fractions) and extreme (<5 fractions) hypofractionated radiation therapy in prostate cancer is yielding favorable results, both in terms of maintained biochemical response and toxicity. Several hypofractionation (HF) schemes for the treatment of prostate cancer are available, although there is considerable variability in the techniques used to manage intra-/interfraction motion and deliver radiation doses. We performed a review of the published studies on HF regimens as a topic of interest for the Stereotactic Ablative Radiotherapy working group, which is part of the Italian Association of Medical Physics. Aspects of organ motion management (imaging for contouring, target volume definition, and rectum/bladder preparation) and treatment delivery (prostate localization, image guided radiation therapy strategy and frequency) were evaluated and categorized to assess outcome relative to disease control and toxicity. Despite the heterogeneity of the data, some interesting trends that emerged from the review might be useful in identifying an optimum HF strategy.
intensity-modulated radiotherapy; stereotactic body radiotherapy; phase-II trial; neoadjuvant androgen deprivation; external-beam radiotherapy; image-guided radiotherapy; long-term outcomes; randomized-trial; conformal radiotherapy; accelerated radiotherapy
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Article (author)
File in questo prodotto:
File Dimensione Formato  
Clemente_IJROBP_2015.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 315.2 kB
Formato Adobe PDF
315.2 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/250788
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 32
  • ???jsp.display-item.citation.isi??? 30
social impact