OBJECTIVE: The aims of the present study were to investigate the main demographic and clinical characteristics, comorbidity patterns, use in association and tolerability of pregabalin in a sample of patients with affective disorders, and to compare demographic and clinical variables of the groups divided, according to the treatment pregabalin was associated with. METHODS: One hundred and fourteen consecutive outpatients, with anxiety and/or depressive disorders with or without comorbidity, were started on pregabalin, assessed and interviewed and their demographic data, associated therapy, tolerability and side effects collected over an observational period of 6 months. RESULTS: The most frequent primary diagnoses were mood disorders (49.1%) and generalized anxiety disorder (21.9%). The most commonly associated treatments were antidepressants (66.7%) and mood stabilizers (15.8%). The most frequent side effects were sedation (3.4%), dizziness (0.9%), nausea (0.9%), diarrhea (0.9%), cough (0.9%) and peripheral edema (0.9%). When patients were divided according to the co-treatments, subgroups differed in terms of prescription of benzodiazepines (χ(2) = 15.25, df = 6, p = 0.013, phi = 0.37), with the most frequent use of these molecules in patients co-treated with tricyclic antidepressants and minor use in the selective serotonin reuptake inhibitors group. CONCLUSIONS:Differences in the co-administration of benzodiazepines might suggest a stronger anxiolytic effect when pregabalin is combined with specific psychotropic drugs (e.g., SSRIs).
Tolerability and use in co-administration of pregabalin in affective patients : a 6-month prospective naturalistic study / C. Dobrea, M. Buoli, C. Arici, G. Camuri, B. Dell'Osso, A. Altamura. - In: EXPERT OPINION ON DRUG SAFETY. - ISSN 1474-0338. - 11:6(2012 Nov), pp. 893-899.
|Titolo:||Tolerability and use in co-administration of pregabalin in affective patients : a 6-month prospective naturalistic study|
DOBREA, CRISTINA ROXANA MIHAELA (Corresponding)
BUOLI, MASSIMILIANO (Secondo)
DELL'OSSO, BERNARDO MARIA (Penultimo)
ALTAMURA, ALFREDO CARLO (Corresponding)
|Parole Chiave:||affective disorders; benzodiazepines; polytherapy; pregabalin; tolerability|
|Settore Scientifico Disciplinare:||Settore MED/25 - Psichiatria|
|Data di pubblicazione:||nov-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1517/14740338.2012.720971|
|Appare nelle tipologie:||01 - Articolo su periodico|