The 75Se internal bioavailability was investigated in microalgae, mussels and rats as biological experimental models. The 75Se accumulation from freshwater to microalgae [Scenedesmus obliquus (Turpin) Kützing], from freshwater to mussels (Unio mancus Lamark) and, finally, per os to rats (Rattus norvegicus Berkenhout) was followed using 75Se-labelled selenite looking at 75Se uptake, retention, intracellular distribution and binding with cellular biocomplexes. After exposure to 10, 50 and 500 μg Se L−1, the microalgae showed an inhibitory effect on population growth only at the highest concentration. Mussels exposed to 105 μg Se L−1 showed an accumulation of the element with time in all tissues. Intracellularly, Se was present in all subcellular fractions, especially in the cytosol. Rats were treated via oral administration with 5 μg Se rat−1. After 24 h, liver and kidney showed the highest Se concentration.

Uptake from water, internal distribution and bioaccumulation of selenium in scenedesmus obliquus, unio mancus and rattus norvegicus : part A / A. Polettini, S. Fortaner, M. Farina, F. Groppi, S. Manenti, G. Libralato, E. Sabbioni. - In: BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY. - ISSN 0007-4861. - 94:1(2015 Jan), pp. 84-89. [10.1007/s00128-014-1407-2]

Uptake from water, internal distribution and bioaccumulation of selenium in scenedesmus obliquus, unio mancus and rattus norvegicus : part A

F. Groppi;S. Manenti;
2015

Abstract

The 75Se internal bioavailability was investigated in microalgae, mussels and rats as biological experimental models. The 75Se accumulation from freshwater to microalgae [Scenedesmus obliquus (Turpin) Kützing], from freshwater to mussels (Unio mancus Lamark) and, finally, per os to rats (Rattus norvegicus Berkenhout) was followed using 75Se-labelled selenite looking at 75Se uptake, retention, intracellular distribution and binding with cellular biocomplexes. After exposure to 10, 50 and 500 μg Se L−1, the microalgae showed an inhibitory effect on population growth only at the highest concentration. Mussels exposed to 105 μg Se L−1 showed an accumulation of the element with time in all tissues. Intracellularly, Se was present in all subcellular fractions, especially in the cytosol. Rats were treated via oral administration with 5 μg Se rat−1. After 24 h, liver and kidney showed the highest Se concentration.
Bioavailability; Microalgae; Mussels; Rats; Selenium; Water uptake; Health, Toxicology and Mutagenesis; Pollution; Toxicology
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore BIO/07 - Ecologia
Settore CHIM/12 - Chimica dell'Ambiente e dei Beni Culturali
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/249313
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