The chromonic stacking mode of short oligomeric DNA upon forming liquid crystalline phases presents an intriguing possibility for liquid crystal autocatalysis, the promotion, by LC ordering, of chemical synthesis that stabilizes LC ordering. In such a scenario the concentration and physical organization of ligation reactants and the fluidity of the liquid crystal phase promotes the appropriate chemical ligation of oligomers. Because it is a mode of elongation free of other catalysts, this offers a tantalizing means of oligonucleotide self-elongation that might have implications in prebiotic life. We present here work toward elucidating possible catalytic enhancement by liquid crystalline phase formation. Ligation approaches based on water soluble carbodiimide base activation and photopolymerization will be presented.

Ligation of complementary oligomers in liquid crystals of nanoDNA / G. Smith, D. Walba, N.A. Clark, W. Xi, T. Gong, C. Bowman, T. Fraccia, G. Zanchetta, T. Bellini. ((Intervento presentato al convegno American Physical Society March Meeting tenutosi a Boston nel 2012.

Ligation of complementary oligomers in liquid crystals of nanoDNA

T. Fraccia;G. Zanchetta
Penultimo
;
T. Bellini
Ultimo
2012

Abstract

The chromonic stacking mode of short oligomeric DNA upon forming liquid crystalline phases presents an intriguing possibility for liquid crystal autocatalysis, the promotion, by LC ordering, of chemical synthesis that stabilizes LC ordering. In such a scenario the concentration and physical organization of ligation reactants and the fluidity of the liquid crystal phase promotes the appropriate chemical ligation of oligomers. Because it is a mode of elongation free of other catalysts, this offers a tantalizing means of oligonucleotide self-elongation that might have implications in prebiotic life. We present here work toward elucidating possible catalytic enhancement by liquid crystalline phase formation. Ligation approaches based on water soluble carbodiimide base activation and photopolymerization will be presented.
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Ligation of complementary oligomers in liquid crystals of nanoDNA / G. Smith, D. Walba, N.A. Clark, W. Xi, T. Gong, C. Bowman, T. Fraccia, G. Zanchetta, T. Bellini. ((Intervento presentato al convegno American Physical Society March Meeting tenutosi a Boston nel 2012.
Conference Object
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/248474
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact