Clinical registries are established as tools for auditing clinical standards and benchmarking quality improvement initiatives. They also have an emerging role (as electronic health records) in cardiovascular research and, in particular, the conduct of Randomized Controlled Clinical Trials (RCTs). Whilst the RCT is accepted as the most robust experimental design, observational data from clinical registries has become increasingly valuable for RCTs. Data from clinical registries may be used to augment results from RCTs, identify patients for recruitment and as an alternative when randomization is not practically possible or ethically desirable. Here we appraise the advantages and disadvantages of both methodologies, with the aim of clarifying when their joint use may be successful.

Contemporary roles of registries in clinical cardiology : when do we need randomized trials? / F. Ieva, C. Gale, L.D. Sharples. - In: EXPERT REVIEW OF CARDIOVASCULAR THERAPY. - ISSN 1477-9072. - 12:12(2014), pp. 1383-1386. [10.1586/14779072.2015.982096]

Contemporary roles of registries in clinical cardiology : when do we need randomized trials?

F. Ieva
Primo
;
2014

Abstract

Clinical registries are established as tools for auditing clinical standards and benchmarking quality improvement initiatives. They also have an emerging role (as electronic health records) in cardiovascular research and, in particular, the conduct of Randomized Controlled Clinical Trials (RCTs). Whilst the RCT is accepted as the most robust experimental design, observational data from clinical registries has become increasingly valuable for RCTs. Data from clinical registries may be used to augment results from RCTs, identify patients for recruitment and as an alternative when randomization is not practically possible or ethically desirable. Here we appraise the advantages and disadvantages of both methodologies, with the aim of clarifying when their joint use may be successful.
Clinical cardiology; Clinical practice; Clinical registries; Evidence based medicine; Observational data; Randomized controlled trials; Routinely collected data
Settore SECS-S/01 - Statistica
Settore MED/01 - Statistica Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/247677
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