The Letter reports a safe and reliable synthesis of aryl 1,2,3-triazoles from the corresponding anilines via intermediate aryl azides, using a continuous process. The method was applied to a variety of substrates with good to excellent yields, without the need to isolate the reactive and possibly unstable intermediates which were constantly kept at low concentration in the matrix environment.
Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor / F. Stazi, D. Cancogni, L. Turco, P. Westerduin, S. Bacchi. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 51:41(2010 Aug 01), pp. 5385-5387.
|Titolo:||Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor|
CANCOGNI, DAMIANO (Secondo)
BACCHI, SERGIO (Corresponding)
|Parole Chiave:||1,3-Cycloaddition; Aryl 1,2,3-triazoles; Flow chemistry; Organic azides; Biochemistry; Organic Chemistry; Drug Discovery3003 Pharmaceutical Science|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||1-ago-2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.tetlet.2010.07.149|
|Appare nelle tipologie:||01 - Articolo su periodico|