The use of a group of indole compounds of formula (I) is described for treating tumours which have developed resistance to antitumour drugs. The compounds of formula (I) can be used in monotherapy, to treat tumours affected by drug resistance, or in co-therapy, as synergistic enhancers of the action of the aforesaid antitumour drugs. In addition, pharmaceutical compositions are described which comprise the indole derivatives of formula (I) in association with antitumour drugs the activity of which is to be enhanced

Indole derivatives useful for treating resistance to antitumor agents / C. Farina, P. Misiano, F. Zunino.

Indole derivatives useful for treating resistance to antitumor agents

P. Misiano
Secondo
;
2005

Abstract

The use of a group of indole compounds of formula (I) is described for treating tumours which have developed resistance to antitumour drugs. The compounds of formula (I) can be used in monotherapy, to treat tumours affected by drug resistance, or in co-therapy, as synergistic enhancers of the action of the aforesaid antitumour drugs. In addition, pharmaceutical compositions are described which comprise the indole derivatives of formula (I) in association with antitumour drugs the activity of which is to be enhanced
NiKem Research S.r.l
Istituto Nazionale dei Tumori Milano
WO2005/105048
PCT/EP05/51910
Resistance antitumor indoles
Settore CHIM/08 - Chimica Farmaceutica
Settore MED/04 - Patologia Generale
Indole derivatives useful for treating resistance to antitumor agents / C. Farina, P. Misiano, F. Zunino.
File in questo prodotto:
File Dimensione Formato  
US2007299084A1.pdf

accesso riservato

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 846.97 kB
Formato Adobe PDF
846.97 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
WO2005105078A1.pdf

accesso riservato

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 1.37 MB
Formato Adobe PDF
1.37 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/246799
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact