PURPOSE OF REVIEW: To summarize recent studies on in-vivo confocal microscopy (IVCM) findings in ocular allergy and dry eye disease (DED), highlighting the role of IVCM in the advancement of knowledge of these diseases. RECENT FINDINGS: IVCM provided new data on ocular surface changes in both ocular allergy and DED. Corneal and conjunctival epithelial and inflammatory cells, corneal nerves, and Meibomian glands showed peculiar patterns of abnormalities, not easily discernable with current clinical exams in these two diseases and their subtypes. At present, small sample size of researches, and poor standardization and evidence of image analysis and interpretation are the most challenging issues. SUMMARY: Ocular allergy and DED are common and increasing healthcare problems, and need better understanding of pathogenesis and natural history, more reliable endpoints, and more tailored diagnostic and therapeutic approaches. IVCM allows quick, noninvasive, steady-state respectful examination of the ocular surface at cellular level to be performed and has potential to be used in the future as a biomarker and to contribute to optimize the tailored management of these diseases.
In-vivo confocal microscopy of the ocular surface : ocular allergy and dry eye / E. Villani, F. Mantelli, P. Nucci. - In: CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY. - ISSN 1528-4050. - 13:5(2013 Oct), pp. 569-576.
|Titolo:||In-vivo confocal microscopy of the ocular surface : ocular allergy and dry eye|
VILLANI, EDOARDO (Primo)
NUCCI, PAOLO (Ultimo)
|Parole Chiave:||conjunctiva; cornea; dry eye disease; in-vivo confocal microscopy; ocular allergy; animals; cornea; dry eye syndromes; epithelial cells; eye; humans; hypersensitivity; image processing, computer-assisted; meibomian glands; microscopy, confocal; immunology and allergy; immunology|
|Settore Scientifico Disciplinare:||Settore MED/30 - Malattie Apparato Visivo|
|Data di pubblicazione:||ott-2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/ACI.0b013e328364ec92|
|Appare nelle tipologie:||01 - Articolo su periodico|