It was once believed that sperm protein 17 (Sp17) was expressed exclusively in the testis and that its sole function was to bind to the oocyte during fertilization. However, immunohistochemistry of the human respiratory airways and reproductive systems show that it is abundant in ciliated cells but not in human cells with stereocilia and microvilli. The high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP)-binding motif within this region, suggest that Sp17 plays a regulatory role in a PKA-independent AKAP complex in both male germinal and ciliated somatic cells.
Sperm protein 17 is expressed in human somatic ciliated epithelia / F. Grizzi, M. Chiriva-Internati, B. Franceschini, K. Bumm, P. Colombo, M. Ciccarelli, E. Donetti, N. Gagliano, P.L. Hermonat, R.K. Bright, M. Gioia, N. Dioguardi, W.M. Kast. - In: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. - ISSN 0022-1554. - 52:4(2004), pp. 549-554. [10.1177/002215540405200414]
Sperm protein 17 is expressed in human somatic ciliated epithelia
E. Donetti;N. Gagliano;M. Gioia;
2004
Abstract
It was once believed that sperm protein 17 (Sp17) was expressed exclusively in the testis and that its sole function was to bind to the oocyte during fertilization. However, immunohistochemistry of the human respiratory airways and reproductive systems show that it is abundant in ciliated cells but not in human cells with stereocilia and microvilli. The high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP)-binding motif within this region, suggest that Sp17 plays a regulatory role in a PKA-independent AKAP complex in both male germinal and ciliated somatic cells.
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