The synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function. Most of the compounds did not show cytotoxicity for MDCK cells.
Azapropellanes with anti-influenza a virus activity / E. Torres, R. Leiva, S. Gazzarrini, M. Rey-Carrizo, M. Frigolé-Vivas, A. Moroni, L. Naesens, S. Vázquez. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 5:7(2014), pp. 831-836. [10.1021/ml500108s]
Azapropellanes with anti-influenza a virus activity
S. Gazzarrini;A. Moroni;
2014
Abstract
The synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function. Most of the compounds did not show cytotoxicity for MDCK cells.
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ml500108s.pdf
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